The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina
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The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina
Purpose Retinal ganglion cells (RGC) can be categorized into roughly 30 distinct subtypes. How these subtypes develop is poorly understood, in part because few unique subtype markers have been characterized. We tested whether the Prdm16 transcription factor is expressed by RGCs as a class or within particular ganglion cell subtypes. Methods Embryonic and mature retinal sections and flatmount ...
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5. Aronson, S.: The uvea, Arch. Ophthalmol. 77: 696, 1967. 6. Rocklin, R. F., Sheremata, W. A., Feldman, R. C , et al.: Cellular response in GuillionBarre and multiple sclerosis, N. Engl. J. Med. 284: 803, 1971. 7. Alepa, F. P. Zvaifler, N. J., and Sliwinski, A. J.: Immunologic effects of cyclophosphamide in rheumatoid arthritis, Arthritis Rheum. 13: 754, 1970. 8. Bloom, B. R.: In vitro approac...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2017
ISSN: 1552-5783
DOI: 10.1167/iovs.17-22442